AimonKopera MD
Epigenetic Theory of Aging
Some people age faster than others.Recent studies have shown that environmental differences such as the air we breathe, the food we eat and drink and even how we move, can influence oxidative damage at the cellular level by activating the “switching center” controlling the genome, what is known as the epigenome, which induces biological changes.
Mounting evidence shows that epigenome can be stimulated to influence the aging process and also slow or reverse the aging process. For example, Zeatin, a cytokinin plant growth
factor, has been shown to have youth preserving and anti-aging effects on human adult skin fibroblasts. Kinetin (Kn) a synthetic cytokinin plant growth hormone delays the onset of aging characteristics in human fibroblasts, a cell in connective tissue that produces collagen and other fibers.
Not only Zeatin has been shown to protect the skin, it also increases the activity of known anti-oxidant enzymes that naturally fight aging. It has been shown to protect animals against neuronal toxicity induced by age specific factors, and in the laboratory setting, to inhibit cancer cell growth and induce their differentiation back into normal cells.
References:
1 Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts
undergoing aging in vitro., Rattan SI1, Sodagam L. Rejuvenation Res. 2005 Spring;8
(1):46-57.
2 Kinetin delays the onset of ageing characteristics in human fibroblasts. Rattan SI1,
Clark BF. BiochemBiophys Res Commun. 1994 Jun 15;201(2):665-72.
3 Plant growth hormone kinetin delays ageing, prolongs the lifespan and slows down
development of the fruitflyZaprionusparavittiger.
4 Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human
Skin Cell LongetivityHussain S1, Malik F1, Mahmood S2. Oxid Med Cell Longev.
2015;2015:709628. doi: 10.1155/2015/709628. Epub 2015 Sep 10.
5 Review: an exposition of medicinal preponderance of Moringaoleifera (Lank.).
Hussain S1, Malik F1, Mahmood S2. Pak J Pharm Sci. 2014 Mar;27(2):397-403.
